Which statement about ARBs is correct?

• A. They increase bradykinin levels
• B. They inhibit ACE
• C. They do not affect bradykinin metabolism
• D. They promote synthesis of angiotensin II

Answer: (C)

ARBs work by blocking the AT1 receptor for angiotensin II, so they prevent angiotensin II from producing vasoconstriction and aldosterone release. Because they do not inhibit the angiotensin‑converting enzyme, bradykinin degradation remains unchanged, so bradykinin levels are not increased with ARB use. The other statements mix up the mechanism: ARBs do not inhibit ACE, they do not directly increase bradykinin, and they do not actively promote synthesis of angiotensin II (any rise in Ang II levels if it occurs is a reflex from increased renin release, not a direct drug action).