Which of the following drugs works by inhibiting HIV integrase, thereby preventing DNA transfer from the viral genome?

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Multiple Choice

Which of the following drugs works by inhibiting HIV integrase, thereby preventing DNA transfer from the viral genome?

Explanation:
Raltegravir works by blocking HIV integrase, the enzyme that inserts the viral DNA into the host cell’s genome. By inhibiting the strand transfer step, it prevents the viral DNA from becoming integrated, so the infection cannot establish itself and viral replication is halted. The other drugs act at different points in the viral lifecycle: cidofovir inhibits viral DNA polymerase, maraviroc blocks the CCR5 receptor to prevent entry, and atazanavir inhibits the viral protease needed for maturation.

Raltegravir works by blocking HIV integrase, the enzyme that inserts the viral DNA into the host cell’s genome. By inhibiting the strand transfer step, it prevents the viral DNA from becoming integrated, so the infection cannot establish itself and viral replication is halted. The other drugs act at different points in the viral lifecycle: cidofovir inhibits viral DNA polymerase, maraviroc blocks the CCR5 receptor to prevent entry, and atazanavir inhibits the viral protease needed for maturation.

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