Which of the following compounds is correctly matched with one of its therapeutic uses? I. Raloxifene: Advanced breast cancer II. Propylthiouracil : Hypothyroidism III. Finasteride: BPH IV. Metformin: PCOS

• A. III only
• B. I, III
• C. III, IV
• D. I, II, III, IV

Answer: (C)

Understanding how a drug works helps you see its approved uses. Raloxifene is a selective estrogen receptor modulator that acts as an estrogen antagonist in breast tissue and an agonist in bone. It’s used to prevent osteoporosis and to reduce breast cancer risk in certain women, not to treat advanced breast cancer. Propylthiouracil is an antithyroid drug that lowers thyroid hormone production, so it treats hyperthyroidism, not hypothyroidism. Finasteride inhibits the enzyme that converts testosterone to dihydrotestosterone, which helps relieve symptoms of benign prostatic hyperplasia. Metformin improves insulin sensitivity and lowers liver glucose production, and it’s used in type 2 diabetes as well as in PCOS to improve ovulatory function. So the correct matches are Finasteride for BPH and Metformin for PCOS, making the combination that includes those two the right choice.