Which drug is a thiazolidinedione (PPAR gamma agonist) used in type 2 diabetes?

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Multiple Choice

Which drug is a thiazolidinedione (PPAR gamma agonist) used in type 2 diabetes?

Explanation:
Thiazolidinediones activate PPAR gamma to improve insulin sensitivity in fat, muscle, and liver, helping lower blood glucose in type 2 diabetes. Pioglitazone is a thiazolidinedione and acts as a PPAR gamma agonist, making it the drug in this list that fits the class. Metformin lowers hepatic glucose production (not PPAR gamma activation). Glipizide is a sulfonylurea that increases insulin release from the pancreas. Sitagliptin is a DPP-4 inhibitor that enhances incretin effects. Because pioglitazone uniquely belongs to the thiazolidinedione class, it is the best answer.

Thiazolidinediones activate PPAR gamma to improve insulin sensitivity in fat, muscle, and liver, helping lower blood glucose in type 2 diabetes. Pioglitazone is a thiazolidinedione and acts as a PPAR gamma agonist, making it the drug in this list that fits the class. Metformin lowers hepatic glucose production (not PPAR gamma activation). Glipizide is a sulfonylurea that increases insulin release from the pancreas. Sitagliptin is a DPP-4 inhibitor that enhances incretin effects. Because pioglitazone uniquely belongs to the thiazolidinedione class, it is the best answer.

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