Which drug is a DPP-4 inhibitor used to treat type 2 diabetes?

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Multiple Choice

Which drug is a DPP-4 inhibitor used to treat type 2 diabetes?

Explanation:
DPP-4 inhibitors work by blocking the enzyme that breaks down incretin hormones (GLP-1 and GIP). With DPP-4 inhibited, incretins stay active longer, boosting glucose-dependent insulin secretion and reducing glucagon after meals, which helps lower blood glucose in type 2 diabetes. Sitagliptin is a DPP-4 inhibitor, so it directly applies this mechanism, making it the best answer. Metformin lowers hepatic glucose production and improves insulin sensitivity. Pioglitazone is a thiazolidinedione that also improves insulin sensitivity. Nateglinide is a meglitinide that stimulates insulin release through a different mechanism.

DPP-4 inhibitors work by blocking the enzyme that breaks down incretin hormones (GLP-1 and GIP). With DPP-4 inhibited, incretins stay active longer, boosting glucose-dependent insulin secretion and reducing glucagon after meals, which helps lower blood glucose in type 2 diabetes. Sitagliptin is a DPP-4 inhibitor, so it directly applies this mechanism, making it the best answer.

Metformin lowers hepatic glucose production and improves insulin sensitivity. Pioglitazone is a thiazolidinedione that also improves insulin sensitivity. Nateglinide is a meglitinide that stimulates insulin release through a different mechanism.

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