Which ADP receptor inhibitor binds reversibly to their receptor?

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Multiple Choice

Which ADP receptor inhibitor binds reversibly to their receptor?

Explanation:
Reversible binding to the ADP receptor means the drug blocks platelet activation only while it’s present, with the effect fading as the drug is cleared. Ticagrelor is a direct-acting P2Y12 receptor antagonist that binds reversibly, so its antiplatelet effect wears off more quickly after stopping the drug. It’s not a prodrug and doesn’t require metabolic activation. In contrast, the other agents are thienopyridines that require hepatic activation and then bind irreversibly to the receptor, producing a lasting effect until new platelets are formed. Therefore, ticagrelor is the reversible ADP receptor inhibitor.

Reversible binding to the ADP receptor means the drug blocks platelet activation only while it’s present, with the effect fading as the drug is cleared. Ticagrelor is a direct-acting P2Y12 receptor antagonist that binds reversibly, so its antiplatelet effect wears off more quickly after stopping the drug. It’s not a prodrug and doesn’t require metabolic activation. In contrast, the other agents are thienopyridines that require hepatic activation and then bind irreversibly to the receptor, producing a lasting effect until new platelets are formed. Therefore, ticagrelor is the reversible ADP receptor inhibitor.

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