True about drug distribution except

• A. Tetracycline may accumulate in the bone because complexes are formed with Calcium
• B. Lipid-soluble may accumulate in adipose tissue because of partitioning of the drug
• C. Diseases like meningitis makes the BBB more permeable to the penetration of drugs into the brain
• D. Drugs distribute slightly more rapid into the adipose tissues and slightly slower into the liver

Answer: (D)

Understanding how drugs distribute in the body depends on tissue blood flow and the drug’s properties, especially lipid solubility and tissue binding. Tetracycline can bind calcium and form complexes, which leads to accumulation in bone. Lipid-soluble drugs tend to partition into adipose tissue and can accumulate there as a reservoir, prolonging their effects. In meningitis, the inflammation can disrupt the blood-brain barrier, making it more permeable and allowing greater drug penetration into the brain. The statement that distribution occurs slightly more rapidly into adipose tissue and slightly slower into the liver isn’t consistent with physiology: adipose tissue has relatively lower blood flow, so initial distribution to fat is slower, whereas the liver receives high blood flow and tends to take up drugs more quickly.