Pamidronate sodium is indicated for the treatment of

• A. Crohn's disease
• B. Ménière's disease
• C. Paget's disease
• D. Hansen's disease

Answer: (C)

Pamidronate sodium is a bisphosphonate that inhibits osteoclast-mediated bone resorption. In Paget's disease, bone remodeling is accelerated and disorganized due to excessive osteoclast activity, leading to weakened, deformed bones and bone pain. By suppressing osteoclasts, pamidronate lowers bone turnover, helps restore a more normal bone structure, and often reduces pain and abnormal bone turnover markers. The other conditions listed—Crohn's disease (intestinal inflammation), Ménière's disease (inner ear disorder), and Hansen's disease (leprosy)—do not involve abnormal bone resorption treated by bisphosphonates, making Paget's disease the correct indication.