Pamidronate sodium is indicated for the treatment of Paget's disease.

• A. Crohn's disease
• B. Ménière's disease
• C. Paget's disease
• D. Hansen's disease

Answer: (C)

Pamidronate sodium is a bisphosphonate that binds to bone and inhibits osteoclast-mediated bone resorption. In Paget's disease, bone remodeling is abnormally rapid, with osteoclasts breaking down bone too quickly and osteoblasts forming new bone in a disorganized way, leading to thickened, structurally weak bones and often painful deformities. By suppressing osteoclast activity, pamidronate reduces bone turnover, helps relieve bone pain, and can stabilize or improve bone structure, making it a suitable treatment for Paget's disease. The other conditions listed—Crohn's disease, Ménière's disease, and Hansen's disease—do not involve excessive bone resorption, so pamidronate air is not indicated for them.