Desmopressin is best described as a selective agonist for which vasopressin receptor?

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Multiple Choice

Desmopressin is best described as a selective agonist for which vasopressin receptor?

Explanation:
Desmopressin mainly activates the V2 receptor, the receptor on kidney collecting ducts that governs water reabsorption. When V2 is stimulated, it triggers a cascade via Gs and increases cAMP, causing aquaporin-2 channels to insert into the apical membrane. This allows more water to be reabsorbed from the filtrate, producing an antidiuretic effect. The drug is designed to favor this receptor, so it achieves its water-conserving action with minimal vasoconstrictive effects that would come from activating V1 receptors. The V1b receptor, tied to pituitary ACTH release, is not the primary target, and V2b is not the receptor responsible for the classic antidiuretic response.

Desmopressin mainly activates the V2 receptor, the receptor on kidney collecting ducts that governs water reabsorption. When V2 is stimulated, it triggers a cascade via Gs and increases cAMP, causing aquaporin-2 channels to insert into the apical membrane. This allows more water to be reabsorbed from the filtrate, producing an antidiuretic effect. The drug is designed to favor this receptor, so it achieves its water-conserving action with minimal vasoconstrictive effects that would come from activating V1 receptors. The V1b receptor, tied to pituitary ACTH release, is not the primary target, and V2b is not the receptor responsible for the classic antidiuretic response.

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